Fine-Tuning Reception in the Bone: PPARγ and Company

نویسندگان

  • Z. Elizabeth Floyd
  • Sanjin Zvonic
  • Mark E. Nuttall
  • Jeffrey M. Gimble
چکیده

PPARgamma plays a central role in the formation of fat. Regulation of PPARgamma activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPARgamma with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPARgamma activity and how these interactions may affect osteogenesis.

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عنوان ژورنال:
  • PPAR Research

دوره 2006  شماره 

صفحات  -

تاریخ انتشار 2006